Generation of 2.1 μm wavelength from degenerate high gray track resistant potassium titanyl phosphate optical parametric oscillator

This paper presents the experimental results of degenerate optical parametric generation using a high gray track resistant potassium titanyl phosphate (HGTR KTP) optical parametric oscillator (OPO). An average output power of 7 W at 10 kHz has been achieved that includes both signal and idler powers near degeneracy using 20 W average power from a 1064 nm Nd:YVO₄ pump source corresponding to an optical conversion efficiency of 35%.     

Neutron detector array at IUAC: Design features and instrumentation developments

The characteristics and performance of the newly commissioned neutron detector array at IUAC are described. The array consists of 100 BC501 liquid scintillators mounted in a semi-spherical geometry and are kept at a distance of 175 cm from the reaction point. Each detector is a 5^″ × 5^″ cylindrical cell coupled to 5^″ diameter photomultiplier tube (PMT). Signal processing is realized using custom-designed home-made integrated electronic modules which perform neutron – gamma discrimination using zero cross timing and time-of-flight (TOF) technique. Compact custom built high voltage power supply developed using DC–DC converters are used to bias the detector. The neutrons are recorded in coincidence with fission fragments which are detected using multi-wire proportional counters mounted inside a 1 m diameter SS target chamber. The detectors and electronics have been tested off-line using radioactive sources and the results are presented.     

A new palladium catalyzed protocol for atom-efficient cross-coupling reactions of triarylbismuths with aryl halides and triflates

A new palladium catalyzed protocol for an atom-efficient cross-coupling reaction of triarylbismuths with aryl halides and triflates has been described. The palladium catalytic system with Cs₂CO₃ base was found to be very efficient in DMA solvent to furnish excellent yields of cross-coupled functionalized biaryls in short reaction times.     

TGF-β1 induction of the adenine nucleotide translocator 1 in astrocytes occurs through Smads and Sp1 transcription factors

Background  

The adenine nucleotide translocator 1 (Ant1) is an inner mitochondrial membrane protein involved with energy mobilization during oxidative phosphorylation. We recently showed that rodent Ant1 is upregulated by transforming growth factor-beta (TGF-β) in reactive astrocytes following CNS injury. In the present study, we describe the molecular mechanisms by which TGF-β1 regulates Ant1 gene expression in cultured primary rodent astrocytes.     

Efficiency of the Incomplete Enumeration Algorithm for Monte-Carlo Simulation of Linear and Branched Polymers

We study the efficiency of the incomplete enumeration algorithm for linear and branched polymers. There is a qualitative difference in the efficiency in these two cases. The average time to generate an independent sample of configuration of polymer with n monomers varies as n ² for linear polymers for large n, but as exp(cn ^α) for branched (undirected and directed) polymers, where 0<α<1. On the binary tree, our numerical studies for n of order 10⁴ gives α = 0.333±0.005. We argue that α =1/3 exactly in this case. An erratum to this article can be found at .     

Synthesis and structural characterisation of new Re(III) complexes using aldimines of α-amino acids as coligands

Complexes of the general formula [Re^III(L)Cl(PPh₃)₂] have been synthesised by reacting H₂L and [ReOCl₃(PPh₃)₂] in ethanol. Here H₂L represents imines of α-amino acids (glycine, l-alanine, l-valine, l-phenylalanine) derived from salicylaldehyde and naphthaldehyde. The crystal structure of one complex has been determined. The complexes are mononuclear, paramagnetic and display paramagnetic ¹H NMR in CDCl₃ solution. Their spectral and redox properties are scrutinised.     

One pot,three component 1,3 dipolar cycloaddition: Regio and diastereoselective synthesis of spiropyrrolidinyl indenoquinoxaline derivatives

A competent and highly discriminating one-pot synthesis of highly diversified novel functionalized indenoquinoxalone grafted spiropyrrolidine linked chromene-3-carbonitrile conjugates accumulating three pharmocophoric cores, heterocyclic indenoquinoxalone, pyrrolidines and chromene-3-carbonitrile in a single molecular framework by means of 1,3-dipolar cycloaddition reaction between indenoquinoxalone, proline/benzyl amine and chromene-3-carbonitrile in ethanol under classical and microwave conditions is described. The three component 1,3-dipolar cycloaddition reaction proceeds via in situ generation of azomethine ylides by the decarboxylative condensation of indenoquinoxalone with proline/benzyl amine and their selectivity towards the endo cyclic double bonds of dipolarophile (chromene-3-carbonitrile) leading to the formation of highly functionalised regio- and diastereoselective molecular hybrids. This methodology exemplifies the green chemistry protocol such as mild reaction conditions, high yields, one-pot procedure and operational simplicity.     

Reactive Oxygen Species Play an Important Role in the Bactericidal Activity of Quinolone Antibiotics

Recent studies posit that reactive oxygen species (ROS) contribute to the cell lethality of bactericidal antibiotics. However, this conjecture has been challenged and remains controversial. To resolve this controversy, we adopted a strategy that involves DNA polymerase IV (PolIV). The nucleotide pool of the cell gets oxidized by ROS and PolIV incorporates the damaged nucleotides (especially 8oxodGTP) into the genome, which results in death of the bacteria. By using a combination of structural and biochemical tools coupled with growth assays, it was shown that selective perturbation of the 8oxodGTP incorporation activity of PolIV results in considerable enhancement of the survival of bacteria in the presence of the norfloxacin antibiotic. Our studies therefore indicate that ROS induced in bacteria by the presence of antibiotics in the environment contribute significantly to cell lethality.